Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice (2024)

Abstract

The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.

Original languageEnglish
Article number386
JournalCellular and Molecular Life Sciences
Volume79
Issue number7
DOIs
StatePublished - Jul 2022
Externally publishedYes

Keywords

  • Bifidobacterium
  • Fetus
  • Metabolism
  • Microbiota
  • Pregnancy

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Lopez-Tello, J., Schofield, Z., Kiu, R., Dalby, M. J., van Sinderen, D., Le Gall, G., Sferruzzi-Perri, A. N., & Hall, L. J. (2022). Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. Cellular and Molecular Life Sciences, 79(7), Article 386. https://doi.org/10.1007/s00018-022-04379-y

Lopez-Tello, Jorge ; Schofield, Zoe ; Kiu, Raymond et al. / Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. In: Cellular and Molecular Life Sciences. 2022 ; Vol. 79, No. 7.

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abstract = "The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.",

keywords = "Bifidobacterium, Fetus, Metabolism, Microbiota, Pregnancy",

author = "Jorge Lopez-Tello and Zoe Schofield and Raymond Kiu and Dalby, {Matthew J.} and {van Sinderen}, Douwe and {Le Gall}, Gw{\'e}na{\"e}lle and Sferruzzi-Perri, {Amanda N.} and Hall, {Lindsay J.}",

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Lopez-Tello, J, Schofield, Z, Kiu, R, Dalby, MJ, van Sinderen, D, Le Gall, G, Sferruzzi-Perri, AN & Hall, LJ 2022, 'Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice', Cellular and Molecular Life Sciences, vol. 79, no. 7, 386. https://doi.org/10.1007/s00018-022-04379-y

Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. / Lopez-Tello, Jorge; Schofield, Zoe; Kiu, Raymond et al.
In: Cellular and Molecular Life Sciences, Vol. 79, No. 7, 386, 07.2022.

Research output: Contribution to journalArticlepeer-review

TY - JOUR

T1 - Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice

AU - Lopez-Tello, Jorge

AU - Schofield, Zoe

AU - Kiu, Raymond

AU - Dalby, Matthew J.

AU - van Sinderen, Douwe

AU - Le Gall, Gwénaëlle

AU - Sferruzzi-Perri, Amanda N.

AU - Hall, Lindsay J.

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PY - 2022/7

Y1 - 2022/7

N2 - The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.

AB - The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.

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KW - Fetus

KW - Metabolism

KW - Microbiota

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JO - Cellular and Molecular Life Sciences

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Lopez-Tello J, Schofield Z, Kiu R, Dalby MJ, van Sinderen D, Le Gall G et al. Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. Cellular and Molecular Life Sciences. 2022 Jul;79(7):386. doi: 10.1007/s00018-022-04379-y

Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice (2024)
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